MEDICAL ROBOTS: Robotic self-modulation enhances implantable long-acting drug delivery devices
参考中译:医疗机器人：机器人自我调节增强了可植入的长效药物输送装置


          

刊名：Science Robotics
作者：Tejal Desai（School of Engineering, Brown University）
Alessandro Grattoni（Department of Nanomedicine, Houston Methodist Research Institute）
刊号：737B0239/I
出版年：2023
年卷期：2023, vol.8, no.81
页码：8292-1--8292-3
总页数：3
分类号：TP24
语种：eng
文摘：Integrating fibrotic capsule sensing with soft robotics may boost long-term performance of implantable drug delivery devices. Long-acting (LA) drug delivery implants play an important role in medicine because they offer a solution for sustained and controlled release of medications, reducing the need for frequent dosing and improving patient compliance. These implants hold great potential for preventing and treating chronic conditions and provide therapeutic benefits over an extended period, enhancing the overall drug effectiveness. Upon deployment, LA drug delivery implants trigger foreign body response (FBR), which involves inflammation, tissue remodeling, and fibrosis (1). In numerous instances, FBR leads to a complete fibrotic encapsulation of the implant, which could compromise its function and longevity. Sustained low-dose LA devices relying on drug diffusion across nanoporous or nanofluidic membranes are unaffected by fibrotic encapsulation (2). In contrast, fibrosis can substantially influence the performance of LA systems that use convection to achieve drug delivery across micro- and macro-orifices. This is the case of infusion pumps and intrathecal drug delivery systems that rely on catheters to convectively deliver medications into the body and specific tissues. Fibrotic encapsulation may also impair the function of drug delivery implants designed for pulsatile drug delivery (3) or emergency medicine, requiring larger boluses of medication to be delivered within the body within seconds or minutes. The formation of fibrous tissue around the orifices can obstruct drug delivery and alter the release profile, leading to unpredictable and suboptimal therapeutic outcomes.
参考中译：将纤维性胶囊传感与软机器人技术相结合，可能会提高植入型药物输送设备的长期性能。长效(LA)给药植入物在医学上发挥着重要作用，因为它们为药物的持续和受控释放提供了解决方案，减少了频繁给药的需要，并提高了患者的依从性。这些植入物在预防和治疗慢性病方面具有巨大潜力，并在较长时间内提供治疗益处，提高整体药物效果。在部署时，LA药物输送植入物会引发异体反应(FBR)，其中涉及炎症、组织重塑和纤维化(1)。在许多情况下，FBR会导致植入物完全被纤维包裹，这可能会影响其功能和寿命。依赖于药物通过纳米孔膜或纳米流体膜扩散的持续低剂量LA设备不受纤维包裹的影响(2)。相比之下，纤维化可以显著影响LA系统的性能，该系统利用对流通过微孔和宏孔实现药物输送。这就是输液泵和鞘内药物输送系统的情况，它们依靠导管对流地将药物输送到体内和特定组织。纤维性胶囊也可能损害为脉冲式药物输送(3)或急诊药物设计的药物输送植入物的功能，需要在几秒钟或几分钟内在体内输送更大剂量的药物。孔口周围纤维组织的形成可能会阻碍药物的输送，改变药物的释放情况，导致不可预测的和次优的治疗结果。



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