Application of additively manufactured 3D scaffolds for bone cancer treatment: a review
参考中译:加成型三维支架在骨癌治疗中的应用


          

刊名：Bio-Design and Manufacturing
作者：Hou, Yanhao（Univ Manchester）
Wang, Weiguang（Univ Manchester）
Bartolo, Paulo（Univ Manchester）
刊号：780E0029
ISSN：2096-5524
出版年：2022
年卷期：2022, vol.5, no.3
页码：556-579
总页数：24
分类号：TH; Q81
关键词：Additive manufacturing；Biomanufacturing；Bone cancer；Implants；Tissue engineering；DRUG-DELIVERY；EWINGS-SARCOMA；TUMOR-THERAPY；SPONTANEOUS REGRESSION；COMPOSITE SCAFFOLDS；PROGNOSTIC-FACTORS；RADIATION-THERAPY；LIMB SALVAGE；SOFT-TISSUE；SELENIUM
参考中译：添加剂制造；生物制造；骨癌；植入物；组织工程；药物输送；尤文斯肉瘤；肿瘤治疗；自发退化；复合支架；预后因素；放射治疗；保肢；软组织；硒
语种：eng
文摘：Bone cancer is a critical health problem on a global scale, and the associated huge clinical and economic burdens are still rising. Although many clinical approaches are currently used for bone cancer treatment, these methods usually affect the normal body functions and thus present significant limitations. Meanwhile, advanced materials and additive manufacturing have opened up promising avenues for the development of new strategies targeting both bone cancer treatment and post-treatment bone regeneration. This paper presents a comprehensive review of bone cancer and its current treatment methods, particularly focusing on a number of advanced strategies such as scaffolds based on advanced functional materials, drug-loaded scaffolds, and scaffolds for photothermal/magnetothermal therapy. Finally, the main research challenges and future perspectives are elaborated.
参考中译：骨癌在全球范围内是一个严重的健康问题，与之相关的巨大临床和经济负担仍在上升。尽管目前许多临床方法用于骨癌的治疗，但这些方法通常会影响正常的身体功能，因此存在很大的局限性。与此同时，先进材料和添加剂制造为开发针对骨癌治疗和治疗后骨再生的新策略开辟了有希望的途径。本文对骨肿瘤及其治疗方法进行了全面的综述，重点介绍了基于先进功能材料的支架、载药支架和光热/磁热治疗支架等先进策略。最后，阐述了本研究面临的主要挑战和未来展望。



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